• Question: what gives chloroform its property to make people unconcsious

    Asked by fluorinefaiza to Peter, Mark, Jony, Ben on 22 Nov 2011.
    • Photo: Jony Hudson

      Jony Hudson answered on 22 Nov 2011:

      It’s amazing but in fact, nobody really knows how anesthetics like choloroform work!

      I was looking something up about this a few weeks ago, as we use a gas in my lab that has anesthetic properties. I found this really great graph called the Meyer-Overton plot:

      It shows that anesthetics work better when they are able to dissolve in fat. The theory is that the anesthetic dissolves in the very thin layer of fat that surrounds the nerve cells, and stops them from functioning properly. This is what is thought to knock people out and make them stop feeling pain.

      I should say, by the way, that I’m not an expert on any of this stuff. I just read loads about it on Wikipedia a few weeks back!!

      p.s. found this great quote on Wikipedia:

      “On 4 November 1847, the Scottish obstetrician James Young Simpson discovered the anaethestic qualities of chloroform when he and his friends were experimenting with different substances on themselves in search of a replacement for ether as a general anesthesia.”


      You wouldn’t be allowed to do that these days 🙂